Performance & GH axis
MK-677
Ibutamoren
Technically not a peptide but a non-peptide growth hormone secretagogue. Taken orally, it mimics ghrelin to stimulate sustained growth hormone release.
Also known as: MK677, MK-0677, Nutrobal
- Status
- MK-677 is a research compound and not approved by the FDA for human use.
- Evidence
- Human trials. Published clinical trials in people report results.
- Half-life
- ~24 hours
- How it's taken
- Oral capsule or liquid
- Mechanism
- Growth-hormone secretagogue
- Pathways
- GH-releasing peptide, GH axis
How MK-677 works
Binds to the ghrelin receptor (GHSR) in the brain, tricking your body into thinking it needs to release growth hormone. Unlike injectable peptides, it works orally and has a long duration of action.
What research has looked at
- Oral administration (no injections)
- Sustained GH elevation for 24 hours
- Improved sleep quality
- Increased muscle mass and bone density
- Enhanced recovery
Evidence level: Human trials. Published clinical trials in people report results. These are areas studied or reported, not promised effects.
Reported side effects and risks
- Increased appetite (significant)
- Water retention and bloating
- Numbness/tingling in hands
- Elevated blood sugar
- Lethargy
- Joint pain
- Potential long-term insulin resistance
Sources
- PubMed research on ibutamoren MK-677 ghrelin mimetic · NIH · National Library of Medicine
- DrugBank record for ibutamoren · DrugBank
- Active clinical trials for ibutamoren MK-677 · U.S. National Library of Medicine
Track MK-677 in Peptide Vault
Log every dose, set reminders on your own schedule, rotate injection sites and keep your vials organized. Peptide Vault records what you enter. It doesn't recommend compounds or doses. iPhone, on-device.
Related compounds
MK-677 FAQ
What is MK-677?
Technically not a peptide but a non-peptide growth hormone secretagogue. Taken orally, it mimics ghrelin to stimulate sustained growth hormone release.
How does MK-677 work?
Binds to the ghrelin receptor (GHSR) in the brain, tricking your body into thinking it needs to release growth hormone. Unlike injectable peptides, it works orally and has a long duration of action.
Is MK-677 FDA approved?
No. MK-677 is a research compound and not approved by the FDA for human use. Evidence level: human trials. Published clinical trials in people report results.
What is the half-life of MK-677?
Reported half-life: ~24 hours.
How is MK-677 taken?
Oral capsule or liquid.
What side effects have been reported with MK-677?
Reported in the sources: Increased appetite (significant); Water retention and bloating; Numbness/tingling in hands; Elevated blood sugar; Lethargy; Joint pain; Potential long-term insulin resistance.
Educational summary compiled from the sources listed above. Not medical advice. Peptide Vault does not sell, source or recommend any compound. Talk to a qualified clinician before starting or changing anything.