Performance & GH axis
GHRP-6
Growth Hormone Releasing Peptide 6
One of the original growth hormone secretagogues. Strongly stimulates growth hormone release and is known for significantly increasing appetite — sometimes used specifically for that purpose.
Also known as: Growth Hormone Releasing Peptide-6, GHRP6
- Status
- GHRP-6 is a research compound and not approved by the FDA for human use.
- Evidence
- Early human data. Only small or early-phase studies in people so far.
- Half-life
- ~15-60 minutes
- How it's taken
- Subcutaneous injection, 2-3x daily
- Mechanism
- Growth-hormone secretagogue
- Pathways
- GH-releasing peptide, GH axis
How GHRP-6 works
Binds to the ghrelin receptor in the pituitary gland, triggering a powerful burst of growth hormone. Also stimulates appetite through the same ghrelin pathway, which can be a benefit or side effect depending on goals.
What research has looked at
- Strong growth hormone release
- Significant appetite stimulation
- May support muscle growth
- Promotes deeper sleep
- One of the most studied GH secretagogues
Evidence level: Early human data. Only small or early-phase studies in people so far. These are areas studied or reported, not promised effects.
Reported side effects and risks
- Intense hunger (very common)
- Water retention
- Elevated cortisol and prolactin
- Tingling and numbness
- Potential blood sugar increase
- Injection site irritation
Sources
- PubMed research on GHRP-6 growth hormone releasing peptide 6 · NIH · National Library of Medicine
- DrugBank record for GHRP-6 · DrugBank
- Active clinical trials for GHRP-6 · U.S. National Library of Medicine
Track GHRP-6 in Peptide Vault
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GHRP-6 FAQ
What is GHRP-6?
One of the original growth hormone secretagogues. Strongly stimulates growth hormone release and is known for significantly increasing appetite — sometimes used specifically for that purpose.
How does GHRP-6 work?
Binds to the ghrelin receptor in the pituitary gland, triggering a powerful burst of growth hormone. Also stimulates appetite through the same ghrelin pathway, which can be a benefit or side effect depending on goals.
Is GHRP-6 FDA approved?
No. GHRP-6 is a research compound and not approved by the FDA for human use. Evidence level: early human data. Only small or early-phase studies in people so far.
What is the half-life of GHRP-6?
Reported half-life: ~15-60 minutes.
How is GHRP-6 taken?
Subcutaneous injection, 2-3x daily.
What side effects have been reported with GHRP-6?
Reported in the sources: Intense hunger (very common); Water retention; Elevated cortisol and prolactin; Tingling and numbness; Potential blood sugar increase; Injection site irritation.
Educational summary compiled from the sources listed above. Not medical advice. Peptide Vault does not sell, source or recommend any compound. Talk to a qualified clinician before starting or changing anything.