Performance & GH axis
Hexarelin
Examorelin
The most potent growth hormone releasing peptide in the GHRP family. Produces the strongest GH pulse but the body develops tolerance to it faster than other GHRPs.
Also known as: EP-23905
- Status
- Hexarelin is a research compound and not approved by the FDA for human use.
- Evidence
- Early human data. Only small or early-phase studies in people so far.
- Half-life
- ~70 minutes
- How it's taken
- Subcutaneous injection
- Mechanism
- Growth-hormone secretagogue
- Pathways
- GH-releasing peptide, GH axis
How Hexarelin works
Binds powerfully to ghrelin receptors in the pituitary, creating the largest growth hormone surge of any GHRP. Also has direct effects on heart muscle cells, which is being studied for cardiac protection.
What research has looked at
- Strongest GH release of all GHRPs
- Potential cardioprotective effects
- Significant muscle recovery support
- Increases IGF-1 levels
Evidence level: Early human data. Only small or early-phase studies in people so far. These are areas studied or reported, not promised effects.
Reported side effects and risks
- Rapid tolerance development (effectiveness decreases)
- Significant cortisol and prolactin increase
- Water retention
- Hunger increase
- Tingling and numbness
Sources
- PubMed research on hexarelin examorelin growth hormone · NIH · National Library of Medicine
- DrugBank record for hexarelin · DrugBank
- Active clinical trials for hexarelin · U.S. National Library of Medicine
Track Hexarelin in Peptide Vault
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Related compounds
Hexarelin FAQ
What is Hexarelin?
The most potent growth hormone releasing peptide in the GHRP family. Produces the strongest GH pulse but the body develops tolerance to it faster than other GHRPs.
How does Hexarelin work?
Binds powerfully to ghrelin receptors in the pituitary, creating the largest growth hormone surge of any GHRP. Also has direct effects on heart muscle cells, which is being studied for cardiac protection.
Is Hexarelin FDA approved?
No. Hexarelin is a research compound and not approved by the FDA for human use. Evidence level: early human data. Only small or early-phase studies in people so far.
What is the half-life of Hexarelin?
Reported half-life: ~70 minutes.
How is Hexarelin taken?
Subcutaneous injection.
What side effects have been reported with Hexarelin?
Reported in the sources: Rapid tolerance development (effectiveness decreases); Significant cortisol and prolactin increase; Water retention; Hunger increase; Tingling and numbness.
Educational summary compiled from the sources listed above. Not medical advice. Peptide Vault does not sell, source or recommend any compound. Talk to a qualified clinician before starting or changing anything.