Research compounds
N-Acetyl Semax Amidate
NA-Semax-Amidate
N-Acetyl Semax Amidate is a chemically modified form of Semax, itself a synthetic analogue of ACTH(4-10) developed and registered in Russia. The acetylated and amidated form is sold as a research peptide and is not approved by the FDA or EMA.
Also known as: NASA, N-Acetyl Semax, Semax amidate
- Status
- N-Acetyl Semax Amidate is a research compound and not approved by the FDA for human use.
- Evidence
- Anecdotal. Mostly community reports; there is no controlled human data.
- Half-life
- Not established for the modified form; unmodified Semax is cleared very rapidly.
- How it's taken
- Intranasal in non-clinical use
- Mechanism
- Cognitive / mood
- Pathways
- Neurotrophic
How N-Acetyl Semax Amidate works
Semax is a fragment analogue of adrenocorticotropic hormone stripped of corticotropic activity. Its reported effects are attributed to increases in brain-derived neurotrophic factor and nerve growth factor expression, and to modulation of dopaminergic and serotonergic systems. Acetylating the N-terminus and amidating the C-terminus is intended to slow enzymatic degradation, extending duration relative to unmodified Semax.
What research has looked at
- Semax is registered in Russia for stroke and cognitive indications, and Russian-language literature reports nootropic and neuroprotective effects.
- The chemical modifications plausibly increase metabolic stability, which is the stated rationale for the variant.
- Intranasal delivery avoids injection, and the parent compound has a long record of clinical use in Russia with a benign reported side-effect profile.
Evidence level: Anecdotal. Mostly community reports; there is no controlled human data. These are areas studied or reported, not promised effects.
Reported side effects and risks
- The evidence base is almost entirely Russian-language, much of it not replicated to Western regulatory standards, and there are no adequate Western controlled trials. The modified form specifically has essentially no published human data of its own.
- It is not approved by the FDA or EMA for any indication.
- Material sold as NA-Semax-Amidate is research chemical supply with unverified identity, purity, sterility and dose accuracy.
- Reported effects are subjective and drawn largely from user accounts rather than controlled data.
- Long-term consequences of chronic neurotrophic factor modulation are unstudied.
Sources
- PubMed research on N-acetyl Semax amidate nootropic · NIH · National Library of Medicine
- DrugBank record for Semax · DrugBank
- Active clinical trials for Semax · U.S. National Library of Medicine
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Related compounds
N-Acetyl Semax Amidate FAQ
What is N-Acetyl Semax Amidate?
N-Acetyl Semax Amidate is a chemically modified form of Semax, itself a synthetic analogue of ACTH(4-10) developed and registered in Russia. The acetylated and amidated form is sold as a research peptide and is not approved by the FDA or EMA.
How does N-Acetyl Semax Amidate work?
Semax is a fragment analogue of adrenocorticotropic hormone stripped of corticotropic activity. Its reported effects are attributed to increases in brain-derived neurotrophic factor and nerve growth factor expression, and to modulation of dopaminergic and serotonergic systems. Acetylating the N-terminus and amidating the C-terminus is intended to slow enzymatic degradation, extending duration relative to unmodified Semax.
Is N-Acetyl Semax Amidate FDA approved?
No. N-Acetyl Semax Amidate is a research compound and not approved by the FDA for human use. Evidence level: anecdotal. Mostly community reports; there is no controlled human data.
How is N-Acetyl Semax Amidate taken?
Intranasal in non-clinical use.
What side effects have been reported with N-Acetyl Semax Amidate?
Reported in the sources: The evidence base is almost entirely Russian-language, much of it not replicated to Western regulatory standards, and there are no adequate Western controlled trials. The modified form specifically has essentially no published human data of its own; It is not approved by the FDA or EMA for any indication; Material sold as NA-Semax-Amidate is research chemical supply with unverified identity, purity, sterility and dose accuracy; Reported effects are subjective and drawn largely from user accounts rather than controlled data; Long-term consequences of chronic neurotrophic factor modulation are unstudied.
Educational summary compiled from the sources listed above. Not medical advice. Peptide Vault does not sell, source or recommend any compound. Talk to a qualified clinician before starting or changing anything.