Research compounds
Dihexa
N-hexanoic-Tyr-Ile-(6) aminohexanoic amide
An extremely potent cognitive-enhancing peptide — up to 10 million times more potent than BDNF at promoting new neural connections. Developed at Washington State University.
Also known as: PNB-0408
- Status
- Dihexa is a research compound and not approved by the FDA for human use.
- Evidence
- Preclinical. Evidence comes from animal or lab studies; effects in people are not established.
- Half-life
- Under investigation
- How it's taken
- Oral or subcutaneous (research only)
- Mechanism
- Cognitive / mood
- Pathways
- Neurotrophic
How Dihexa works
Activates hepatocyte growth factor (HGF) and its receptor c-Met in the brain. This stimulates the formation of new synaptic connections (synaptogenesis) and promotes neuronal survival.
What research has looked at
- Extraordinary synaptogenic potency
- May improve memory in cognitive decline
- Promotes new neural connections
- Potential in Alzheimer's research
- Active at very low doses
Evidence level: Preclinical. Evidence comes from animal or lab studies; effects in people are not established. These are areas studied or reported, not promised effects.
Reported side effects and risks
- Very limited safety data
- Potential for uncontrolled cell growth (theoretical)
- Unknown long-term neurological effects
- Not tested in clinical trials
- Significant safety concerns due to potency
Sources
- PubMed research on dihexa angiotensin IV analog cognition · NIH · National Library of Medicine
- DrugBank record for dihexa · DrugBank
- StatPearls / NCBI Bookshelf on dihexa N-hexanoic · NCBI Bookshelf
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Related compounds
Dihexa FAQ
What is Dihexa?
An extremely potent cognitive-enhancing peptide — up to 10 million times more potent than BDNF at promoting new neural connections. Developed at Washington State University.
How does Dihexa work?
Activates hepatocyte growth factor (HGF) and its receptor c-Met in the brain. This stimulates the formation of new synaptic connections (synaptogenesis) and promotes neuronal survival.
Is Dihexa FDA approved?
No. Dihexa is a research compound and not approved by the FDA for human use. Evidence level: preclinical. Evidence comes from animal or lab studies; effects in people are not established.
What is the half-life of Dihexa?
Reported half-life: Under investigation.
How is Dihexa taken?
Oral or subcutaneous (research only).
What side effects have been reported with Dihexa?
Reported in the sources: Very limited safety data; Potential for uncontrolled cell growth (theoretical); Unknown long-term neurological effects; Not tested in clinical trials; Significant safety concerns due to potency.
Educational summary compiled from the sources listed above. Not medical advice. Peptide Vault does not sell, source or recommend any compound. Talk to a qualified clinician before starting or changing anything.