Research compounds
Cortagen
Ala-Glu-Asp-Pro, AEDP
Cortagen is a synthetic tetrapeptide from the Khavinson bioregulator family developed in Russia, marketed for peripheral nerve and brain function. It is not approved by the FDA or EMA.
Also known as: AEDP, Ala-Glu-Asp-Pro
- Status
- Cortagen is a research compound and not approved by the FDA for human use.
- Evidence
- Anecdotal. Mostly community reports; there is no controlled human data.
- Half-life
- Not established.
- How it's taken
- Injection or oral capsule in non-clinical use
- Mechanism
- Cognitive / mood
- Pathways
- Neurotrophic
How Cortagen works
The Khavinson bioregulator model proposes that short peptides enter cells and nuclei and interact with specific DNA sequences to alter tissue-specific gene expression — here, nervous tissue. This mechanism has not been independently validated outside the originating research group and is not accepted as established pharmacology.
What research has looked at
- Russian-language studies report effects on peripheral nerve regeneration in animal models.
- The tetrapeptide is small enough that some absorption by non-injected routes is plausible in principle.
- The family has a long history of use in Russia with a correspondingly long, if uncontrolled, tolerability record.
Evidence level: Anecdotal. Mostly community reports; there is no controlled human data. These are areas studied or reported, not promised effects.
Reported side effects and risks
- The proposed gene-regulatory mechanism has not been independently replicated, and the bioregulator literature sits outside mainstream peer-reviewed pharmacology. No regulator has approved it, the human evidence base is limited, and material sold under this name is research chemical supply with unverified identity, purity, sterility and dose accuracy.
- No controlled Western clinical trials exist for this compound.
- Neuroregenerative claims are unsupported by controlled human data.
- Long-term safety in humans is unstudied.
Sources
- PubMed research on Khavinson peptide bioregulator cortagen · NIH · National Library of Medicine
- DrugBank record for cortagen · DrugBank
- Active clinical trials for cortagen · U.S. National Library of Medicine
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Related compounds
Cortagen FAQ
What is Cortagen?
Cortagen is a synthetic tetrapeptide from the Khavinson bioregulator family developed in Russia, marketed for peripheral nerve and brain function. It is not approved by the FDA or EMA.
How does Cortagen work?
The Khavinson bioregulator model proposes that short peptides enter cells and nuclei and interact with specific DNA sequences to alter tissue-specific gene expression — here, nervous tissue. This mechanism has not been independently validated outside the originating research group and is not accepted as established pharmacology.
Is Cortagen FDA approved?
No. Cortagen is a research compound and not approved by the FDA for human use. Evidence level: anecdotal. Mostly community reports; there is no controlled human data.
How is Cortagen taken?
Injection or oral capsule in non-clinical use.
What side effects have been reported with Cortagen?
Reported in the sources: The proposed gene-regulatory mechanism has not been independently replicated, and the bioregulator literature sits outside mainstream peer-reviewed pharmacology. No regulator has approved it, the human evidence base is limited, and material sold under this name is research chemical supply with unverified identity, purity, sterility and dose accuracy; No controlled Western clinical trials exist for this compound; Neuroregenerative claims are unsupported by controlled human data; Long-term safety in humans is unstudied.
Educational summary compiled from the sources listed above. Not medical advice. Peptide Vault does not sell, source or recommend any compound. Talk to a qualified clinician before starting or changing anything.