Research compounds
Pinealon
Glu-Asp-Arg, EDR peptide
Pinealon is a synthetic tripeptide (glutamyl-aspartyl-arginine) from the Khavinson bioregulator family developed in Russia, marketed for cognitive and neuroprotective effects. It is not approved by the FDA or EMA and has no substantive Western clinical evidence.
Also known as: Glu-Asp-Arg, EDR peptide
- Status
- Pinealon is a research compound and not approved by the FDA for human use.
- Evidence
- Anecdotal. Mostly community reports; there is no controlled human data.
- Half-life
- Not established.
- How it's taken
- Oral capsule or injection in non-clinical use
- Mechanism
- Cognitive / mood
- Pathways
- Neurotrophic
How Pinealon works
The Khavinson peptide bioregulator hypothesis proposes that short peptides penetrate cells and nuclei and bind specific DNA sequences, altering gene expression in a tissue-specific manner. For Pinealon the proposed target tissue is the brain. It should be stated plainly that this mechanism, while published, has not been independently validated outside the originating research group and is not accepted as established pharmacology.
What research has looked at
- Russian-language studies report neuroprotective effects in animal models of hypoxia and oxidative stress.
- Very short peptides are, in principle, more absorbable orally and transdermally than larger peptides.
- The compounds have a long history of use in Russia and a correspondingly long, if uncontrolled, record of tolerability.
Evidence level: Anecdotal. Mostly community reports; there is no controlled human data. These are areas studied or reported, not promised effects.
Reported side effects and risks
- The proposed gene-regulatory mechanism has not been independently replicated outside the group that originated it, and the Khavinson bioregulator literature as a whole sits well outside mainstream peer-reviewed pharmacology.
- There are no controlled Western clinical trials, and no regulator has approved it.
- Claims regarding lifespan extension and cognitive enhancement in humans are unsupported by controlled data.
- Material sold as Pinealon is supplement or research chemical supply with unverified identity, purity and dose accuracy.
- Long-term safety in humans is unstudied.
Sources
- PubMed research on Pinealon Khavinson peptide bioregulator · NIH · National Library of Medicine
- DrugBank record for Pinealon · DrugBank
- Active clinical trials for Pinealon · U.S. National Library of Medicine
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Related compounds
Pinealon FAQ
What is Pinealon?
Pinealon is a synthetic tripeptide (glutamyl-aspartyl-arginine) from the Khavinson bioregulator family developed in Russia, marketed for cognitive and neuroprotective effects. It is not approved by the FDA or EMA and has no substantive Western clinical evidence.
How does Pinealon work?
The Khavinson peptide bioregulator hypothesis proposes that short peptides penetrate cells and nuclei and bind specific DNA sequences, altering gene expression in a tissue-specific manner. For Pinealon the proposed target tissue is the brain. It should be stated plainly that this mechanism, while published, has not been independently validated outside the originating research group and is not accepted as established pharmacology.
Is Pinealon FDA approved?
No. Pinealon is a research compound and not approved by the FDA for human use. Evidence level: anecdotal. Mostly community reports; there is no controlled human data.
How is Pinealon taken?
Oral capsule or injection in non-clinical use.
What side effects have been reported with Pinealon?
Reported in the sources: The proposed gene-regulatory mechanism has not been independently replicated outside the group that originated it, and the Khavinson bioregulator literature as a whole sits well outside mainstream peer-reviewed pharmacology; There are no controlled Western clinical trials, and no regulator has approved it; Claims regarding lifespan extension and cognitive enhancement in humans are unsupported by controlled data; Material sold as Pinealon is supplement or research chemical supply with unverified identity, purity and dose accuracy; Long-term safety in humans is unstudied.
Educational summary compiled from the sources listed above. Not medical advice. Peptide Vault does not sell, source or recommend any compound. Talk to a qualified clinician before starting or changing anything.