Approved & therapeutic
Semax
Synthetic ACTH Fragment
A synthetic peptide derived from adrenocorticotropic hormone (ACTH). Developed in Russia as a neuroprotective and cognitive-enhancing agent.
Also known as: ACTH 4-10, Semaxon
- Status
- Semax is approved in at least one country outside the U.S. but not approved by the FDA.
- Evidence
- Early human data. Only small or early-phase studies in people so far.
- Half-life
- ~2-3 minutes (biological effects last hours)
- How it's taken
- Intranasal spray
- Mechanism
- Cognitive / mood
- Pathways
- Neurotrophic
How Semax works
Increases BDNF levels in the brain, promotes neuroplasticity, and enhances dopamine and serotonin signaling. Works without affecting cortisol levels despite being derived from ACTH.
What research has looked at
- Enhanced cognitive function and memory
- Neuroprotective properties
- Improved attention and focus
- May support stroke recovery
- Does not raise cortisol
Evidence level: Early human data. Only small or early-phase studies in people so far. These are areas studied or reported, not promised effects.
Reported side effects and risks
- Hair loss (rare, reversible)
- Mild headache
- Nasal irritation
- Potential mood changes
- Limited Western clinical data
Sources
- PubMed research on semax ACTH fragment neuroprotective · NIH · National Library of Medicine
- DrugBank record for semax · DrugBank
- StatPearls / NCBI Bookshelf on semax · NCBI Bookshelf
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Related compounds
Semax FAQ
What is Semax?
A synthetic peptide derived from adrenocorticotropic hormone (ACTH). Developed in Russia as a neuroprotective and cognitive-enhancing agent.
How does Semax work?
Increases BDNF levels in the brain, promotes neuroplasticity, and enhances dopamine and serotonin signaling. Works without affecting cortisol levels despite being derived from ACTH.
Is Semax FDA approved?
No. Semax is approved in at least one country outside the U.S. but not approved by the FDA. Evidence level: early human data. Only small or early-phase studies in people so far.
What is the half-life of Semax?
Reported half-life: ~2-3 minutes (biological effects last hours).
How is Semax taken?
Intranasal spray.
What side effects have been reported with Semax?
Reported in the sources: Hair loss (rare, reversible); Mild headache; Nasal irritation; Potential mood changes; Limited Western clinical data.
Educational summary compiled from the sources listed above. Not medical advice. Peptide Vault does not sell, source or recommend any compound. Talk to a qualified clinician before starting or changing anything.