Research compounds
Humanin
Mitochondrial-Derived Peptide
A 24-amino acid peptide encoded in mitochondrial DNA. One of the first mitochondrial-derived peptides discovered, showing powerful cell-protective properties.
- Status
- Humanin is a research compound and not approved by the FDA for human use.
- Evidence
- Preclinical. Evidence comes from animal or lab studies; effects in people are not established.
- Half-life
- Under investigation
- How it's taken
- Research only — no established protocol
- Mechanism
- Mitochondrial / longevity
- Pathways
- Mitochondrial
How Humanin works
Protects cells from programmed cell death (apoptosis) by interacting with Bax proteins. Also improves insulin signaling and reduces inflammation through STAT3 pathway modulation.
What research has looked at
- Cytoprotective (protects cells from death)
- Neuroprotective — may slow Alzheimer's progression
- Improved insulin sensitivity
- Cardioprotective properties
- Anti-inflammatory
Evidence level: Preclinical. Evidence comes from animal or lab studies; effects in people are not established. These are areas studied or reported, not promised effects.
Reported side effects and risks
- Extremely limited human data
- Mostly studied in lab settings
- Potential unknown interactions
- Not available for clinical use
- Long-term effects unknown
Sources
- PubMed research on humanin mitochondrial derived peptide neuroprotection · NIH · National Library of Medicine
- StatPearls / NCBI Bookshelf on humanin peptide · NCBI Bookshelf
- DrugBank record for humanin · DrugBank
Track Humanin in Peptide Vault
Log every dose, set reminders on your own schedule, rotate injection sites and keep your vials organized. Peptide Vault records what you enter. It doesn't recommend compounds or doses. iPhone, on-device.
Related compounds
Humanin FAQ
What is Humanin?
A 24-amino acid peptide encoded in mitochondrial DNA. One of the first mitochondrial-derived peptides discovered, showing powerful cell-protective properties.
How does Humanin work?
Protects cells from programmed cell death (apoptosis) by interacting with Bax proteins. Also improves insulin signaling and reduces inflammation through STAT3 pathway modulation.
Is Humanin FDA approved?
No. Humanin is a research compound and not approved by the FDA for human use. Evidence level: preclinical. Evidence comes from animal or lab studies; effects in people are not established.
What is the half-life of Humanin?
Reported half-life: Under investigation.
How is Humanin taken?
Research only — no established protocol.
What side effects have been reported with Humanin?
Reported in the sources: Extremely limited human data; Mostly studied in lab settings; Potential unknown interactions; Not available for clinical use; Long-term effects unknown.
Educational summary compiled from the sources listed above. Not medical advice. Peptide Vault does not sell, source or recommend any compound. Talk to a qualified clinician before starting or changing anything.