Longevity
Sermorelin
GHRH (1-29)
The shortest functional fragment of growth hormone releasing hormone. Stimulates your own pituitary gland to produce growth hormone naturally, declining with age.
Also known as: Geref, GHRH 1-29, sermo
- Status
- Sermorelin is a prescription medicine.
- Evidence
- Approved labeling. Official prescribing information exists, based on clinical trials in people.
- Half-life
- ~10-20 minutes
- How it's taken
- Subcutaneous injection, typically at bedtime
- Mechanism
- Growth-hormone secretagogue
- Pathways
- GHRH analogue, GH axis
How Sermorelin works
Binds to GHRH receptors on pituitary cells and triggers your body's own growth hormone production. Because it works through your natural feedback loop, it's considered a gentler approach to GH optimization.
What research has looked at
- Increased natural growth hormone production
- Improved sleep quality
- Better skin elasticity
- Enhanced muscle recovery
- Supports immune function
Evidence level: Approved labeling. Official prescribing information exists, based on clinical trials in people. These are areas studied or reported, not promised effects.
Reported side effects and risks
- Injection site pain or swelling
- Flushing
- Headache
- Dizziness
- Difficulty swallowing (rare)
Sources
- FDA approved-drug listing for sermorelin · U.S. Food & Drug Administration
- DailyMed prescribing information for sermorelin · NIH · DailyMed
- PubMed research on sermorelin growth hormone releasing hormone 1-29 · NIH · National Library of Medicine
- DrugBank record for sermorelin · DrugBank
Track Sermorelin in Peptide Vault
Log every dose, set reminders on your own schedule, rotate injection sites and keep your vials organized. Peptide Vault records what you enter. It doesn't recommend compounds or doses. iPhone, on-device.
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Sermorelin FAQ
What is Sermorelin?
The shortest functional fragment of growth hormone releasing hormone. Stimulates your own pituitary gland to produce growth hormone naturally, declining with age.
How does Sermorelin work?
Binds to GHRH receptors on pituitary cells and triggers your body's own growth hormone production. Because it works through your natural feedback loop, it's considered a gentler approach to GH optimization.
Is Sermorelin FDA approved?
Yes. Sermorelin is a prescription medicine. Evidence level: approved labeling. Official prescribing information exists, based on clinical trials in people.
What is the half-life of Sermorelin?
Reported half-life: ~10-20 minutes.
How is Sermorelin taken?
Subcutaneous injection, typically at bedtime.
What side effects have been reported with Sermorelin?
Reported in the sources: Injection site pain or swelling; Flushing; Headache; Dizziness; Difficulty swallowing (rare).
Educational summary compiled from the sources listed above. Not medical advice. Peptide Vault does not sell, source or recommend any compound. Talk to a qualified clinician before starting or changing anything.