Performance & GH axis
LGD-4033
Ligandrol, VK5211
LGD-4033 is a selective androgen receptor modulator, a small molecule investigated for muscle wasting and hip fracture recovery. It is not approved anywhere and is sold as a research chemical.
Also known as: ligandrol, LGD4033, LGD 4033, VK5211, anabolicum
- Status
- LGD-4033 is a research compound and not approved by the FDA for human use.
- Evidence
- Early human data. Only small or early-phase studies in people so far.
- Half-life
- Approximately 24 to 36 hours.
- How it's taken
- Oral, in non-clinical use
- Mechanism
- Anabolic (IGF-1 / myostatin)
- Pathways
- Androgen
How LGD-4033 works
LGD-4033 is a non-steroidal androgen receptor agonist with high binding affinity and selectivity for muscle and bone over androgenic tissue. Like other SARMs it neither aromatises nor undergoes 5-alpha-reduction, so it does not produce estradiol or dihydrotestosterone through the usual routes.
What research has looked at
- A Phase 1 study in healthy men reported dose-dependent increases in lean body mass over 21 days with a favourable short-term tolerability profile.
- A Phase 2 trial in hip fracture patients examined lean mass and functional recovery.
- Orally active with a half-life supporting once-daily dosing.
Evidence level: Early human data. Only small or early-phase studies in people so far. These are areas studied or reported, not promised effects.
Reported side effects and risks
- It is not approved by any regulator for any indication.
- Dose-dependent suppression of total testosterone, sex hormone binding globulin and HDL cholesterol was documented even in the short Phase 1 study.
- Case reports of drug-induced liver injury in users are published, and the FDA has warned about SARMs as a class on this basis.
- Testosterone suppression may require months to recover and recovery is not guaranteed.
- Prohibited at all times under the WADA Prohibited List; it has caused positive tests including from contaminated supplements.
- Independent analyses of products sold as LGD-4033 have found inaccurate dosing and substitution with other compounds.
Sources
- PubMed research on LGD-4033 ligandrol testosterone suppression · NIH · National Library of Medicine
- DrugBank record for LGD-4033 · DrugBank
- Active clinical trials for LGD-4033 · U.S. National Library of Medicine
Track LGD-4033 in Peptide Vault
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LGD-4033 FAQ
What is LGD-4033?
LGD-4033 is a selective androgen receptor modulator, a small molecule investigated for muscle wasting and hip fracture recovery. It is not approved anywhere and is sold as a research chemical.
How does LGD-4033 work?
LGD-4033 is a non-steroidal androgen receptor agonist with high binding affinity and selectivity for muscle and bone over androgenic tissue. Like other SARMs it neither aromatises nor undergoes 5-alpha-reduction, so it does not produce estradiol or dihydrotestosterone through the usual routes.
Is LGD-4033 FDA approved?
No. LGD-4033 is a research compound and not approved by the FDA for human use. Evidence level: early human data. Only small or early-phase studies in people so far.
What is the half-life of LGD-4033?
Reported half-life: Approximately 24 to 36 hours.
How is LGD-4033 taken?
Oral, in non-clinical use.
What side effects have been reported with LGD-4033?
Reported in the sources: It is not approved by any regulator for any indication; Dose-dependent suppression of total testosterone, sex hormone binding globulin and HDL cholesterol was documented even in the short Phase 1 study; Case reports of drug-induced liver injury in users are published, and the FDA has warned about SARMs as a class on this basis; Testosterone suppression may require months to recover and recovery is not guaranteed; Prohibited at all times under the WADA Prohibited List; it has caused positive tests including from contaminated supplements; Independent analyses of products sold as LGD-4033 have found inaccurate dosing and substitution with other compounds.
Educational summary compiled from the sources listed above. Not medical advice. Peptide Vault does not sell, source or recommend any compound. Talk to a qualified clinician before starting or changing anything.