Weight & metabolic
Semaglutide
GLP-1 Receptor Agonist
Mimics a natural gut hormone (GLP-1) that tells your brain you're full and slows stomach emptying. Originally developed for type 2 diabetes, now widely used for weight management.
Also known as: Ozempic, Wegovy, Rybelsus, GLP-1, sema
- Status
- Semaglutide is approved by the U.S. FDA and has official prescribing information.
- Evidence
- Approved labeling. Official prescribing information exists, based on clinical trials in people.
- Half-life
- ~7 days
- How it's taken
- Weekly subcutaneous injection
- Mechanism
- Incretin (GLP-1 / GIP / glucagon / amylin)
- Pathways
- GLP-1
How Semaglutide works
When you eat, your gut releases GLP-1. Semaglutide acts like a stronger, longer-lasting version of that hormone. It signals your brain's appetite center to reduce hunger and helps your pancreas release the right amount of insulin.
What research has looked at
- Significant appetite reduction
- Improved blood sugar control
- May support cardiovascular health
- Sustained weight loss over time
Evidence level: Approved labeling. Official prescribing information exists, based on clinical trials in people. These are areas studied or reported, not promised effects.
Reported side effects and risks
- Nausea (especially when starting)
- Vomiting or diarrhea
- Stomach pain or bloating
- Constipation
- Fatigue
- Rare: pancreatitis risk
Sources
- FDA approved-drug listing for semaglutide · U.S. Food & Drug Administration
- DailyMed prescribing information for semaglutide · NIH · DailyMed
- PubMed research on semaglutide clinical efficacy · NIH · National Library of Medicine
- DrugBank record for semaglutide · DrugBank
Track Semaglutide in Peptide Vault
Log every dose, set reminders on your own schedule, rotate injection sites and keep your vials organized. Peptide Vault records what you enter. It doesn't recommend compounds or doses. iPhone, on-device.
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Semaglutide FAQ
What is Semaglutide?
Mimics a natural gut hormone (GLP-1) that tells your brain you're full and slows stomach emptying. Originally developed for type 2 diabetes, now widely used for weight management.
How does Semaglutide work?
When you eat, your gut releases GLP-1. Semaglutide acts like a stronger, longer-lasting version of that hormone. It signals your brain's appetite center to reduce hunger and helps your pancreas release the right amount of insulin.
Is Semaglutide FDA approved?
Yes. Semaglutide is approved by the U.S. FDA and has official prescribing information. Evidence level: approved labeling. Official prescribing information exists, based on clinical trials in people.
What is the half-life of Semaglutide?
Reported half-life: ~7 days.
How is Semaglutide taken?
Weekly subcutaneous injection.
What side effects have been reported with Semaglutide?
Reported in the sources: Nausea (especially when starting); Vomiting or diarrhea; Stomach pain or bloating; Constipation; Fatigue; Rare: pancreatitis risk.
Educational summary compiled from the sources listed above. Not medical advice. Peptide Vault does not sell, source or recommend any compound. Talk to a qualified clinician before starting or changing anything.