Approved & therapeutic
KPV
Lysine-Proline-Valine Tripeptide
A small anti-inflammatory tripeptide derived from alpha-MSH. Despite its tiny size (just 3 amino acids), it has potent effects on reducing gut and skin inflammation.
Also known as: Lysine-Proline-Valine, α-MSH fragment
- Status
- KPV is a research compound and not approved by the FDA for human use.
- Evidence
- Preclinical. Evidence comes from animal or lab studies; effects in people are not established.
- Half-life
- ~2-4 hours
- How it's taken
- Oral capsule or topical
- Mechanism
- Tissue repair
How KPV works
Enters cells and inhibits NF-κB, a master switch for inflammation. Also modulates inflammatory cytokines and has direct antimicrobial properties, particularly in the gut.
What research has looked at
- Potent anti-inflammatory
- Gut inflammation reduction (IBD research)
- Antimicrobial activity
- May help with skin conditions
- Orally bioavailable
Evidence level: Preclinical. Evidence comes from animal or lab studies; effects in people are not established. These are areas studied or reported, not promised effects.
Reported side effects and risks
- Limited clinical data
- Mild GI upset
- Potential immune modulation effects
- Not well-studied long-term
- Not FDA-approved
Sources
- PubMed research on KPV lysine proline valine anti-inflammatory · NIH · National Library of Medicine
- StatPearls / NCBI Bookshelf on KPV tripeptide alpha-MSH · NCBI Bookshelf
- DrugBank record for KPV peptide · DrugBank
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KPV FAQ
What is KPV?
A small anti-inflammatory tripeptide derived from alpha-MSH. Despite its tiny size (just 3 amino acids), it has potent effects on reducing gut and skin inflammation.
How does KPV work?
Enters cells and inhibits NF-κB, a master switch for inflammation. Also modulates inflammatory cytokines and has direct antimicrobial properties, particularly in the gut.
Is KPV FDA approved?
No. KPV is a research compound and not approved by the FDA for human use. Evidence level: preclinical. Evidence comes from animal or lab studies; effects in people are not established.
What is the half-life of KPV?
Reported half-life: ~2-4 hours.
How is KPV taken?
Oral capsule or topical.
What side effects have been reported with KPV?
Reported in the sources: Limited clinical data; Mild GI upset; Potential immune modulation effects; Not well-studied long-term; Not FDA-approved.
Educational summary compiled from the sources listed above. Not medical advice. Peptide Vault does not sell, source or recommend any compound. Talk to a qualified clinician before starting or changing anything.