Approved & therapeutic
Gonadorelin
GnRH / Gonadotropin-Releasing Hormone
A synthetic version of the natural hormone that triggers the release of LH and FSH — the hormones that control testosterone and estrogen production. Used to maintain fertility and hormone balance.
Also known as: Factrel, Lutrelef, GnRH, LHRH
- Status
- Gonadorelin is approved by the U.S. FDA and has official prescribing information.
- Evidence
- Approved labeling. Official prescribing information exists, based on clinical trials in people.
- Half-life
- ~2-4 minutes (effects are downstream)
- How it's taken
- Subcutaneous injection
- Mechanism
- Reproductive axis (GnRH / kisspeptin / oxytocin)
- Pathways
- GnRH
How Gonadorelin works
Stimulates the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in a natural pulsatile pattern. This maintains the body's own testosterone or estrogen production.
What research has looked at
- Maintains natural hormone production
- Preserves fertility during hormone therapy
- Diagnostic tool for pituitary function
- Supports healthy testosterone levels
Evidence level: Approved labeling. Official prescribing information exists, based on clinical trials in people. These are areas studied or reported, not promised effects.
Reported side effects and risks
- Headache
- Flushing
- Nausea
- Injection site reactions
- May cause initial hormone surge before regulation
Sources
- FDA approved-drug listing for gonadorelin · U.S. Food & Drug Administration
- DailyMed prescribing information for gonadorelin · NIH · DailyMed
- PubMed research on gonadorelin GnRH pituitary · NIH · National Library of Medicine
- DrugBank record for gonadorelin · DrugBank
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Gonadorelin FAQ
What is Gonadorelin?
A synthetic version of the natural hormone that triggers the release of LH and FSH — the hormones that control testosterone and estrogen production. Used to maintain fertility and hormone balance.
How does Gonadorelin work?
Stimulates the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in a natural pulsatile pattern. This maintains the body's own testosterone or estrogen production.
Is Gonadorelin FDA approved?
Yes. Gonadorelin is approved by the U.S. FDA and has official prescribing information. Evidence level: approved labeling. Official prescribing information exists, based on clinical trials in people.
What is the half-life of Gonadorelin?
Reported half-life: ~2-4 minutes (effects are downstream).
How is Gonadorelin taken?
Subcutaneous injection.
What side effects have been reported with Gonadorelin?
Reported in the sources: Headache; Flushing; Nausea; Injection site reactions; May cause initial hormone surge before regulation.
Educational summary compiled from the sources listed above. Not medical advice. Peptide Vault does not sell, source or recommend any compound. Talk to a qualified clinician before starting or changing anything.