Longevity
5-Amino-1MQ
NNMT Inhibitor
A small molecule that blocks the enzyme NNMT, which depletes NAD+ and slows metabolism. By inhibiting NNMT, it may reverse age-related metabolic decline and support healthy body composition.
Also known as: 5A1MQ, 5 Amino 1MQ
- Status
- 5-Amino-1MQ is a research compound and not approved by the FDA for human use.
- Evidence
- Preclinical. Evidence comes from animal or lab studies; effects in people are not established.
- Half-life
- ~4-6 hours (estimated)
- How it's taken
- Oral capsule
- Mechanism
- Metabolic (non-incretin)
How 5-Amino-1MQ works
Blocks nicotinamide N-methyltransferase (NNMT), an enzyme that becomes overactive with aging and obesity. When NNMT is overactive, it drains NAD+ levels and promotes fat storage. Blocking it restores NAD+ and reactivates fat-burning pathways.
What research has looked at
- Restores cellular NAD+ levels
- May reverse metabolic slowdown
- Supports healthy body composition
- Oral bioavailability
- Targets root cause of metabolic aging
Evidence level: Preclinical. Evidence comes from animal or lab studies; effects in people are not established. These are areas studied or reported, not promised effects.
Reported side effects and risks
- Limited human clinical data
- GI discomfort in some users
- Potential interactions with NAD+ pathways
- Long-term effects unknown
- Not FDA-approved
Sources
- PubMed research on 5-amino-1MQ NNMT inhibitor adipose · NIH · National Library of Medicine
- StatPearls / NCBI Bookshelf on NNMT nicotinamide N-methyltransferase · NCBI Bookshelf
- DrugBank record for 5-Amino-1MQ · DrugBank
Track 5-Amino-1MQ in Peptide Vault
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5-Amino-1MQ FAQ
What is 5-Amino-1MQ?
A small molecule that blocks the enzyme NNMT, which depletes NAD+ and slows metabolism. By inhibiting NNMT, it may reverse age-related metabolic decline and support healthy body composition.
How does 5-Amino-1MQ work?
Blocks nicotinamide N-methyltransferase (NNMT), an enzyme that becomes overactive with aging and obesity. When NNMT is overactive, it drains NAD+ levels and promotes fat storage. Blocking it restores NAD+ and reactivates fat-burning pathways.
Is 5-Amino-1MQ FDA approved?
No. 5-Amino-1MQ is a research compound and not approved by the FDA for human use. Evidence level: preclinical. Evidence comes from animal or lab studies; effects in people are not established.
What is the half-life of 5-Amino-1MQ?
Reported half-life: ~4-6 hours (estimated).
How is 5-Amino-1MQ taken?
Oral capsule.
What side effects have been reported with 5-Amino-1MQ?
Reported in the sources: Limited human clinical data; GI discomfort in some users; Potential interactions with NAD+ pathways; Long-term effects unknown; Not FDA-approved.
Educational summary compiled from the sources listed above. Not medical advice. Peptide Vault does not sell, source or recommend any compound. Talk to a qualified clinician before starting or changing anything.